Research and Publications
CIREN's scientific work integrates basic research with clinical care, advancing neurological restoration through evidence-based medicine.
Bridging Basic Research and Clinical Care
Since its founding in 1989, CIREN has combined a basic research program with a clinical care area, creating a model where scientific investigation directly informs patient treatment. This integration allows findings from the laboratory to be translated into rehabilitation protocols and therapeutic approaches.
The institution's research is grounded in the principle of neuroplasticity — the nervous system's capacity to reorganize and adapt — which underpins the Neuro-Restorative, Multifactorial, Intensive, and Personalized treatment technology developed at CIREN.
Neurorestoration
Mechanisms of neural repair and functional recovery.
Neurodegeneration
Alzheimer's, Parkinson's, and related disorders.
Neurorehabilitation
Intensive, personalized rehabilitation protocols.
Neuropharmacology
Neuroprotective compounds including NeuroEPO.
Three Decades of Translating Research into Care
Since its founding on February 26, 1989, CIREN's research-driven treatment protocols have reached patients worldwide.
Patient volume and country figures are drawn from institutional reporting (Prensa Latina, 2017). The Neuro-Restorative, Multifactorial, Intensive, and Personalized treatment protocol has been refined across these clinics since the institution's founding.
Two Foundational Therapeutic Programs
CIREN's scientific work is organized around two original therapeutic programs, each with an active research agenda.
Neurological Restoration
The flagship program, based on a Neuro-Restorative, Multifactorial, Intensive, and Personalized treatment technology. Research focuses on neuroplasticity, intensive rehabilitation protocols, and the integration of neurosurgical, pharmacological, and rehabilitative approaches across six specialized pathology clinics.
REBIOGER — General Biological Restoration
A biological restoration program aimed at aging and systemic deterioration. Research explores integrative approaches to biological restoration alongside the neurological program.
Notable Scientific Contributions
Selected contributions from CIREN's clinical and research work. Specific statistics and claims are published only with supporting evidence.
Selective Dorsolateral Subthalamotomy
A world-first surgical innovation developed at CIREN for the treatment of Parkinson's disease, using stereotactic minimally-invasive neurosurgery with automated planning and neurophysiological verification.
NeuralCIM® (NeuroEPO) Research
Clinical research on a NeuroEPO-derived medication for neurological conditions, including the ATHENEA randomized clinical trial for mild-to-moderate Alzheimer's disease, published in Alzheimer's Research & Therapy (2023).
Stem Cell Research Program
Ongoing research into stem cell applications for neurological conditions. Stem cell treatment is restricted to research protocols and is not available as a regular clinical treatment.
Intensive Rehabilitation Protocols
Development of personalized, multidisciplinary neuro-rehabilitation delivered in structured cycles, integrating physiotherapy, occupational therapy, and cognitive rehabilitation.
Six Specialized Clinics
Research and clinical care organized across six specialized pathology clinics, each focused on a defined neurological condition group.
ISO 9000 Quality System
A quality control system based on ISO 9000 standards applied to clinical and research processes.
Several historical statistics and achievement claims are pending verification against primary sources. This page is updated as evidence is confirmed.
Selected Published Research
Peer-reviewed publications and registered clinical trials associated with CIREN's scientific work. This is a representative selection, not an exhaustive list.
Erythropoietin nasal drops for mild-to-moderate Alzheimer's disease (ATHENEA trial)
Alzheimer's Research & Therapy
A randomized, double-blind, placebo-controlled trial investigating intranasal NeuroEPO in patients with mild-to-moderate Alzheimer's disease.
NeuroEPO and neuroprotection in neurodegenerative disease
Peer-reviewed journals
A body of research on the neuroprotective properties of a modified erythropoietin formulation developed by the Center of Molecular Immunology (CIM), Cuba.
Stereotactic neurosurgery for Parkinson's disease
Peer-reviewed neurosurgery literature
Publications on selective dorsolateral subthalamotomy and minimally-invasive stereotactic techniques developed at CIREN.
Intensive personalized neuro-rehabilitation protocols
Peer-reviewed rehabilitation literature
Studies on the Neuro-Restorative, Multifactorial, Intensive, and Personalized treatment model applied across CIREN's six specialized clinics.
A comprehensive publications list with DOIs and citation details is in preparation. For specific publication inquiries, contact the International Patient Coordination Desk.
Multidisciplinary Teams
Neurologists, neurosurgeons, rehabilitation physicians, neuropsychologists, and basic researchers working together.
International Collaboration
Research and clinical exchange with institutions and professionals from multiple countries.
Quality Standards
ISO 9000-based quality control applied to both research and clinical processes.
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